A finite element method for thermo-mechanical coupling analysis of shape memory alloys

Due to strong thermo-mechanical coupling in shape memory alloys (SMAs), heat generation/absorption during forward/reverse phase transformation can cause temperature variations in the material; influencing its mechanical behaviour. It is usually assumed that this coupling is only affected by the loading rate. But, recently studies have shown that the size of the structure and the boundary conditions are also important. Therefore, only the definition of quasistatic or slow loading rate can not guarantee an isothermal process and so further considerations need to be made. Based on the powerful model, proposed by Lagoudas et al. [1] and later improved for computer programming using the return mapping algorithm by Qidwai and Lagoudas [2], this contribution presents a three-dimensional thermo-mechanically coupled extension which describes two important typical phenomena of material model of SMAs: superelasticity and superplasticity (shape memory effect). An algorithm is then proposed to implement the coupled model into a finite element code. Performed simulations with different boundary conditions demonstrate that the both loading rate and the size dependency can be captured within the proposed framework. The results are in good agreement with available data in the literature

Prediction of HBF-0259 interactions with hepatitis B Virus receptors and surface antigen secretory factors

Hepatitis B virus (HBV) is an etiological agent of viral hepatitis, which may lead to cirrhosis, and hepatocellular carcinoma. Current treatment strategies have not shown promising effect to date but various complications such as, drug toxicity-resistance have been reported. Study on newly discovered compounds, with minimal side effects, as specific HBV inhibitors is a fundamental subject introducing new biologic drugs. Here, we aimed to, by prediction, estimate interactions of HBF-0259 as a non-toxic anti-HBV compound on inhibiting the HBV through either interaction with the viral entry or HBsAg secreting factors using In Silico procedure. Molecular docking was performed by Hex 8.0.0 software to predict the interaction energy (Etot) between HBF-0259 and known cellular factors involved in HBV entry and HBsAg secreting factors. Hex 8.0.0 also employed to create protein–protein complexes. These interactions were then used to analyze the binding site of HBF-0259 within the assumed receptors by MGLTools software. Finally, the amino acid sequences involved in this interaction were aligned for any conservancy. Here, we showed that HBF-0259 Etot with CypA (–545.41 kcal/mol) and SCCA1 (499.68 kcal/mol), involved in HBsAg secretion and HBV integration, respectively, was higher than other interactions. Furthermore, HBF-0259 predicted interaction energy was even higher than those of CypA inhibitors. In addition, we claim that preS1 and/or preS2 regions within HBsAg are not suitable targets for HBF-0259. HBF-0259 has higher interaction energy with CypA and SCCA1, even more than other known receptors, co-receptors, viral ligands, and secretory factors. HBF-0259 could be introduced as potent anti-viral compound in which CypA and or SCCA1, as previously shown, are involved. © 2016 Indian Virological Societ

Study of anomalous top quark FCNC interactions via tWtW-channel of single top

The potential of the LHC for investigation of anomalous top quark interactions with gluon ($tug,tcg$) through the production of $tW$-channel of single top quark is studied. In the Standard Model, the single top quarks in the $tW$-channel mode are charge symmetric meaning that $\sigma(pp\to t+W^{-}) = \sigma(pp\to \bar{t}+W^{+})$. However, the presence of anomalous FCNC couplings leads to charge asymmetry. In this paper a method is proposed in which this charge asymmetry may be used to constrain anomalous FCNC couplings. The strength of resulting constraints is estimated for the LHC for the center of mass energies of 7 and 14 TeV.Comment: 13 pages, 4 figures, new references adde

Allelic forms of merozoite surface protein-3 in Plasmodium falciparum isolates from southeast of Iran

Background: Genetic diversity has provided Plasmodium falciparum with the potential capacity of avoiding the immune response, and possibly supported the natural selection of drug or vaccine-resistant parasites. Merozoite surface protein-3 (MSP-3) has been used to develop vaccines and investigate the genetic diversity regarding P. falciparum malaria in Iran. Objectives: The main goal of this study was to analyze the polymorphic antigen MSP-3 genes across southeast of Iran among four different districts, to identify the differences in the allele frequency and genetic diversity. Materials and Methods: Nested polymerase chain reaction amplification was used to determine polymorphisms of N-terminal region of the MSP-3 gene. A total of 85 microscopically positive P. falciparum infected individuals from southeast of Iran were included in this study. Results: Of the 85 confirmed P. falciparum samples obtained from four different districts, 72 were successfully scored for MSP-3.The MSP-3 allele classes (K1 and 3D7 types) showed comparable prevalence in all districts. Overall frequencies of K1 and 3D7 allele classes were 94.5 % for both. Conclusions: Since no study has yet looked at the extent of P. falciparum MSP-3 in this geographic region, these data can be helpful to support development of a vaccine based on MSP-3 against malaria. There should be a comparative analysis in different seasonal peaks to indicate the allelic polymorphism of MSP-3 over a period. © 2014, Ahvaz Jundishapur University of Medical Sciences; Published by Kowsar Corp